01 - Whisk buttermilk and hot sauce in a large bowl until combined. Submerge chicken pieces completely in the liquid. Cover bowl and refrigerate for minimum 1 hour, preferably overnight for optimal flavor penetration.
02 - Combine paprika, garlic powder, onion powder, oregano, thyme, cayenne pepper, black pepper, and salt in a small bowl. Mix thoroughly until spices are evenly distributed. Measure and set aside 2 teaspoons for the flour coating.
03 - Mix flour, cornstarch, and the reserved 2 teaspoons of Cajun seasoning in a shallow dish. Whisk together until the seasoning is uniformly incorporated throughout the flour mixture.
04 - Lift chicken from marinade, allowing excess liquid to drip off. Press each piece firmly into the seasoned flour mixture, turning to coat all surfaces evenly. Shake gently to remove loose coating.
05 - Pour vegetable oil to depth of 2 inches in a large Dutch oven or deep skillet. Heat oil until it reaches 350°F as confirmed by a cooking thermometer.
06 - Place chicken pieces in hot oil without overcrowding the pan. Fry for 12 to 15 minutes, turning occasionally, until coating is deep golden brown and internal temperature reaches 165°F. Work in batches as needed.
07 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest for 5 minutes to allow juices to redistribute and coating to set slightly.